Gajdusek, Blumberg, and Prions
نویسندگان
چکیده
منابع مشابه
Prions.
The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...
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Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of "variants," each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and sh...
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We will show that the following set theoretical assumption c = ω2, the dominating number d equals to ω1, and there exists an ω1-generated Ramsey ultrafilter on ω (which is consistent with ZFC) implies that for an arbitrary sequence fn : R → R of uniformly bounded functions there is a set P ⊂ R of cardinality continuum and an infinite W ⊂ ω such that {fn P : n ∈ W} is a monotone uniformly conver...
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plants are cloaked in hundreds of tiny projections, known as trichomes. These structures vary in function, shape, size and spacing from species to species, and it’s not known whether similar cellular differentiation programs are responsible for making trichomes in different plants. Trichomes are clearly visible in the scanning electron micrograph of a wild-type Nicotiana tabacum seedling above ...
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Kuru, the first human transmissible spongiform encephalopathy, was transmitted to chimpanzees by D. Carleton Gajdusek (1923-2008). In this review, I briefly summarize the history of this seminal discovery alongside its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the late...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2013
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.8.101.1